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Insider Transactions by PERCEPTIVE ADVISORS LLC

  Symbol Relationship Date Transaction Cost # Shares Value($) Total Shares Form Form 4
Y! CORI 10% Owner Jan 18, 2018 Buy $12.80 310,000 3,968,000 6,357,133
4
Jan 18, 2018, 05:21 PM
Y! CORI 10% Owner Jan 17, 2018 Buy $12.24 149,650 1,831,716 6,047,133
4
Jan 18, 2018, 05:21 PM
Y! CORI 10% Owner Jan 16, 2018 Buy $11.83 50,350 595,640 5,897,483
4
Jan 18, 2018, 05:21 PM
Y! GBT 10% Owner Dec 19, 2017 Buy $38.00 175,000 6,650,000 4,889,066
4
Dec 19, 2017, 08:22 PM
Y! VBIV 10% Owner Oct 26, 2017 Buy $3.05 3,100,000 9,455,000 9,345,725
4
Oct 30, 2017, 04:11 PM
Y! ZGNX 10% Owner Oct 03, 2017 Buy $37.50 300,000 11,250,000 3,970,357
4
Oct 03, 2017, 02:52 PM
Y! ZGNX 10% Owner Sep 29, 2017 Buy $32.83 222,055 7,290,059 3,670,357
4
Oct 03, 2017, 08:45 AM
Y! VSAR 10% Owner Sep 21, 2017 Sale $3.61 480,000 1,731,802 4,102,984
4
Sep 25, 2017, 04:07 PM
Y! VSAR 10% Owner Sep 22, 2017 Sale $3.20 1,650,000 5,281,750 3,449,563
4
Sep 25, 2017, 04:07 PM
Y! ALDX 10% Owner Sep 19, 2017 Buy $7.25 200,000 1,450,000 3,085,458
4
Sep 21, 2017, 08:45 AM
Y! FOLD 10% Owner Jul 13, 2017 Buy $12.25 1,500,000 18,375,000 17,888,597
4
Jul 14, 2017, 08:30 AM
Y! ACRX 10% Owner Jun 19, 2017 Sale $2.40 875,000 2,100,000 4,533,728
4
Jun 21, 2017, 04:45 PM
Y! CORI 10% Owner May 25, 2017 Buy $6.25 1,902,400 11,890,000 5,546,129
4
May 25, 2017, 10:29 AM
Y! VSAR 10% Owner Feb 13, 2017 Buy $15.51 59,133 917,425 4,229,563
4/A
Mar 14, 2017, 04:30 PM
Y! VSAR 10% Owner Feb 10, 2017 Buy $14.94 34,883 521,281 4,170,430
4/A
Mar 14, 2017, 04:30 PM
Y! VBIV 10% Owner Dec 06, 2016 Buy $3.05 3,383,955 10,321,063 6,245,725
4/A
Mar 09, 2017, 01:36 PM
Y! ALDX 10% Owner Feb 14, 2017 Buy $4.50 893,025 4,018,613 2,589,451
4
Feb 15, 2017, 08:45 AM
Y! VSAR 10% Owner Feb 13, 2017 Buy $15.51 59,133 917,425 4,228,563
4
Feb 14, 2017, 08:45 AM
Y! VSAR 10% Owner Feb 10, 2017 Buy $14.94 34,883 521,281 4,169,430
4
Feb 14, 2017, 08:45 AM
Y! VSAR 10% Owner Feb 08, 2017 Buy $13.51 104,612 1,413,319 4,093,336
4
Feb 10, 2017, 08:45 AM
Y! VSAR 10% Owner Feb 09, 2017 Buy $14.27 41,211 587,928 4,134,547
4
Feb 10, 2017, 08:45 AM
Y! VSAR 10% Owner Dec 30, 2016 Buy $14.66 94,750 1,388,845 4,013,411
4
Jan 04, 2017, 02:26 PM
Y! FOLD 10% Owner Dec 30, 2016 Buy $4.96 94,750 470,055 16,293,847
4
Jan 04, 2017, 02:25 PM
Y! VSAR 10% Owner Dec 29, 2016 Buy $14.37 47,375 680,589 3,918,661
4
Dec 30, 2016, 08:46 AM
Y! FOLD 10% Owner Dec 29, 2016 Buy $4.85 94,750 459,917 16,293,847
4
Dec 30, 2016, 08:45 AM
Y! FOLD 10% Owner Dec 28, 2016 Buy $4.91 47,375 232,706 16,199,097
4
Dec 30, 2016, 08:45 AM
Y! FOLD 10% Owner Dec 23, 2016 Buy $4.81 85,275 410,050 16,151,722
4
Dec 27, 2016, 10:57 AM
Y! FOLD 10% Owner Dec 22, 2016 Buy $4.51 189,500 854,835 16,066,447
4
Dec 23, 2016, 08:31 AM
Y! VBIV 10% Owner Dec 06, 2016 Buy $3.05 3,383,955 10,321,063 6,213,314
4
Dec 08, 2016, 02:23 PM
Y! ACRX 10% Owner Sep 29, 2016 Sale $3.88 97,200 377,117 5,386,410
4
Sep 30, 2016, 04:32 PM
Y! ACRX 10% Owner Sep 28, 2016 Sale $3.96 119,300 472,380 5,483,610
4
Sep 30, 2016, 04:32 PM
Y! ACRX 10% Owner Sep 15, 2016 Sale $3.70 392,850 1,452,811 5,718,833
4
Sep 16, 2016, 04:37 PM
Y! FOLD No longer a 10% Owner. Aug 25, 2016 Sale $6.81 1,100,000 7,491,000 14,139,444
4
Aug 26, 2016, 04:30 PM
Y! ALDX 10% Owner May 26, 2016 Buy $5.00 700,000 3,500,000 1,940,458
4
May 26, 2016, 02:50 PM
Y! ACRX 10% Owner Nov 17, 2015 Sale $5.36 133,900 717,409 6,038,060
4
Nov 19, 2015, 04:15 PM
Y! ACRX 10% Owner Nov 18, 2015 Sale $5.35 42,300 226,132 5,995,760
4
Nov 19, 2015, 04:15 PM
Y! ACRX 10% Owner Nov 06, 2015 Sale $4.47 17,100 76,365 6,171,960
4
Nov 09, 2015, 04:30 PM
Y! ACRX 10% Owner Nov 05, 2015 Sale $4.62 75,000 346,260 6,189,060
4
Nov 09, 2015, 04:30 PM
Y! ALDX 10% Owner Oct 28, 2015 Buy $6.50 45,100 293,150 1,240,458
4
Nov 05, 2015, 04:16 PM
Y! ALDX 10% Owner Oct 26, 2015 Buy $6.46 50,000 323,150 1,195,358
4
Oct 28, 2015, 02:30 PM
Y! ALDX 10% Owner Oct 22, 2015 Buy $6.47 18,020 116,661 1,145,358
4
Oct 26, 2015, 04:05 PM
Y! ALDX 10% Owner Oct 20, 2015 Buy $6.39 37,145 237,193 1,127,338
4
Oct 22, 2015, 11:50 AM
Y! FOLD 10% Owner Oct 07, 2015 Buy $6.27 50,000 313,500 15,239,444
4
Oct 08, 2015, 09:18 AM
Y! FOLD 10% Owner Oct 06, 2015 Buy $6.52 250,000 1,629,000 15,189,444
4
Oct 07, 2015, 10:27 AM
Y! FOLD 10% Owner Oct 05, 2015 Buy $6.81 500,000 3,402,500 14,939,444
4
Oct 07, 2015, 10:27 AM
Y! ACRX 10% Owner Sep 09, 2015 Sale $4.18 310,000 1,294,777 6,264,060
4
Sep 11, 2015, 04:01 PM
Y! VBIV 10% Owner Aug 14, 2015 Buy $2.08 650,000 1,352,000 3,260,356
4
Aug 18, 2015, 06:45 AM
Y! FOLD 10% Owner Nov 19, 2014 Buy $6.50 2,100,000 13,650,000 14,439,444
4
Nov 19, 2014, 02:55 PM
Y! FOLD 10% Owner Jun 30, 2014 Buy $3.50 4,000,000 14,000,000 12,339,444
4
Jul 01, 2014, 10:56 AM
Y! ACRX 10% Owner Nov 07, 2013 Buy $6.50 100,000 649,810 6,574,060
4
Nov 12, 2013, 07:16 AM
Y! ACRX 10% Owner Nov 06, 2013 Buy $6.52 100,000 651,660 6,474,060
4
Nov 12, 2013, 07:16 AM
Y! ACRX 10% Owner Nov 04, 2013 Buy $6.87 155,000 1,064,292 6,374,060
4
Nov 06, 2013, 11:47 AM
Y! ACRX 10% Owner Nov 01, 2013 Buy $7.17 160,660 1,151,900 6,219,060
4
Nov 04, 2013, 01:07 PM
Y! ACRX 10% Owner Oct 31, 2013 Buy $6.69 200,000 1,338,640 6,058,400
4
Nov 04, 2013, 01:07 PM
Y! AEGR 10% Owner Sep 05, 2013 Sale $89.20 750,000 66,899,998 2,873,426
4
Sep 09, 2013, 06:15 PM
Y! AEGR 10% Owner Jun 15, 2013 Option Exercise $25.00 200,000 5,000,000 3,573,426
4
Sep 09, 2013, 06:15 PM
Y! ACRX 10% Owner Jul 23, 2013 Buy $11.65 850,000 9,902,500 5,858,400
4
Jul 24, 2013, 02:26 PM
Y! RPRX 10% Owner Mar 15, 2013 Option Exercise $12.32 2,050,000 25,250,000 2,762,560
4
Mar 20, 2013, 08:20 AM
Y! AEGR 10% Owner Feb 01, 2013 Buy $27.79 50,000 1,389,400 3,373,426
4
Feb 05, 2013, 03:54 PM
Y! AEGR 10% Owner Jan 18, 2013 Buy $27.62 50,000 1,381,000 3,323,426
4
Jan 22, 2013, 01:16 PM
Y! AEGR 10% Owner Jan 17, 2013 Buy $26.73 50,000 1,336,285 3,273,426
4
Jan 18, 2013, 01:57 PM
Y! AEGR 10% Owner Jan 11, 2013 Buy $27.07 475,000 12,857,220 3,223,426
4
Jan 15, 2013, 06:07 PM
Y! AEGR 10% Owner Dec 04, 2012 Buy $21.27 20,000 425,400 2,615,293
4
Dec 05, 2012, 01:05 PM
Y! AEGR 10% Owner Nov 29, 2012 Buy $22.71 30,000 681,300 2,595,293
4
Dec 03, 2012, 02:29 PM
Y! AEGR 10% Owner Nov 15, 2012 Buy $19.50 10,000 195,000 2,455,293
4
Dec 03, 2012, 10:36 AM
Y! AEGR 10% Owner Nov 07, 2012 Buy $21.12 30,000 633,600 2,445,293
4
Dec 03, 2012, 10:36 AM
Y! AEGR 10% Owner Nov 28, 2012 Buy $21.76 70,000 1,523,200 2,565,293
4
Dec 03, 2012, 10:36 AM
Y! AEGR 10% Owner Nov 21, 2012 Buy $20.75 20,000 415,000 2,495,293
4
Dec 03, 2012, 10:36 AM
Y! AEGR 10% Owner Nov 20, 2012 Buy $21.01 20,000 420,200 2,475,293
4
Dec 03, 2012, 10:36 AM
Y! AEGR 10% Owner Oct 19, 2012 Option Exercise $17.50 247,500 4,331,250 2,347,233
4
Dec 03, 2012, 10:34 AM
Y! RPRX 10% Owner May 14, 2012 Buy $7.38 59,500 439,283 2,862,560
4
May 15, 2012, 02:11 PM
Y! RPRX 10% Owner May 11, 2012 Buy $6.35 170,000 1,079,840 2,803,060
4
May 14, 2012, 02:19 PM
Y! RPRX 10% Owner May 10, 2012 Buy $4.82 325,000 1,566,097 2,633,060
4
May 11, 2012, 03:22 PM
Y! RPRX 10% Owner Aug 19, 2011 Buy $5.43 725,600 3,942,000 2,308,060
4
Aug 24, 2011, 10:22 AM
Y! TRMS 10% Owner Aug 19, 2011 Sale $2.01 6,600 13,266 2,333,400
4
Aug 24, 2011, 10:21 AM
Y! TRMS 10% Owner Aug 18, 2011 Sale $2.11 1,500 3,165 2,340,000
4
Aug 24, 2011, 10:21 AM
Y! RPRX 10% Owner Aug 12, 2011 Buy $7.50 800 6,000 1,582,460
4
Aug 17, 2011, 03:42 PM
Y! RPRX 10% Owner Aug 09, 2011 Buy $7.50 3,800 28,500 1,581,660
4
Aug 12, 2011, 01:58 PM
Y! RPRX 10% Owner Aug 08, 2011 Buy $7.50 4,700 35,250 1,577,860
4
Aug 12, 2011, 01:58 PM
Y! RPRX 10% Owner Aug 05, 2011 Buy $7.50 15,100 113,250 1,573,160
4
Aug 12, 2011, 01:58 PM
Y! TRMS 10% Owner Aug 04, 2011 Buy $2.18 10,000 21,800 2,341,500
4
Aug 10, 2011, 03:16 PM
Y! TRMS 10% Owner Aug 03, 2011 Buy $2.22 70,000 155,100 2,331,500
4
Aug 05, 2011, 11:36 AM
Y! RPRX 10% Owner Mar 16, 2011 Buy $5.21 86,500 450,735 1,558,060
4
Mar 18, 2011, 10:33 AM
Y! RPRX 10% Owner Mar 07, 2011 Buy $6.47 30,000 194,100 1,471,560
4
Mar 09, 2011, 12:55 PM
Y! RPRX 10% Owner Mar 01, 2011 Buy $4.62 50,000 231,000 1,441,560
4
Mar 02, 2011, 03:45 PM
Y! RPRX 10% Owner Feb 28, 2011 Buy $4.46 88,273 393,698 1,391,560
4
Mar 01, 2011, 03:55 PM
Y! RPRX 10% Owner Feb 25, 2011 Buy $4.49 48,922 219,660 1,303,287
4
Feb 28, 2011, 03:58 PM
Y! RPRX 10% Owner Feb 24, 2011 Buy $4.36 110,000 479,600 1,254,365
4
Feb 28, 2011, 03:58 PM
Y! PPCO 10% Owner Sep 20, 2010 Option Exercise $5.00 6,476,446 32,382,230 6,476,446
4
Sep 27, 2010, 05:12 PM