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Insider Transactions by BAKER BROS ADVISORS LLC

  Symbol Relationship Date Transaction Cost # Shares Value($) Total Shares Form Form 4
Y! BLCM 10% Owner Jan 17, 2018 Sale $8.63 260,600 2,247,910 4,292,652
4
Jan 19, 2018, 04:57 PM
Y! BLCM 10% Owner Jan 19, 2018 Sale $7.91 295,361 2,336,217 3,734,776
4
Jan 19, 2018, 04:57 PM
Y! BLCM 10% Owner Jan 18, 2018 Sale $8.12 324,774 2,635,768 4,000,484
4
Jan 19, 2018, 04:57 PM
Y! IDRA Director Jan 02, 2018 Option Exercise $2.21 27,999 61,878 16,566,806
4
Jan 04, 2018, 04:04 PM
Y! INCY Director Dec 29, 2017 Option Exercise $94.71 600 56,826 29,247,709
4
Jan 03, 2018, 04:05 PM
Y! ACAD Director Nov 27, 2017 Option Exercise $28.00 1,941 54,348 489,977
4
Nov 29, 2017, 04:00 PM
Y! ACAD Director Nov 27, 2017 Option Exercise $1.38 39,378 54,342 491,918
4
Nov 29, 2017, 04:00 PM
Y! MRTX 10% Owner Nov 08, 2017 Option Exercise $7.86 280,263 2,202,867 2,372,218
4
Nov 13, 2017, 06:04 AM
Y! IDRA Director Oct 26, 2017 Buy $1.50 8,000,000 12,000,000 16,557,473
4
Oct 30, 2017, 05:12 PM
Y! ACAD Director Oct 13, 2017 Option Exercise $35.40 55,457 1,963,178 23,708,408
4
Oct 16, 2017, 05:15 PM
Y! ACAD Director Oct 13, 2017 Option Exercise $1.38 1,426,590 1,968,694 23,763,865
4
Oct 16, 2017, 05:15 PM
Y! RYTM Former 10% owner Oct 05, 2017 Buy $17.00 885,000 15,045,000 1,878,242
4
Oct 06, 2017, 03:58 PM
Y! IDRA Director Oct 02, 2017 Option Exercise $2.28 27,135 61,868 9,352,821
4
Oct 04, 2017, 07:22 PM
Y! GHDX Director Oct 01, 2017 Option Exercise $32.09 3,732 119,760 11,360,448
4
Oct 03, 2017, 05:39 PM
Y! INCY Director Sep 29, 2017 Option Exercise $116.74 486 56,736 29,247,509
4
Oct 03, 2017, 05:30 PM
Y! INCY Director Sep 08, 2017 Buy $132.00 100,000 13,200,000 29,247,347
4
Sep 08, 2017, 05:06 PM
Y! BGNE Director Aug 11, 2017 Buy $71.00 176,056 12,499,976 3,476,256
4
Aug 14, 2017, 03:49 PM
Y! IDRA Director Jul 03, 2017 Option Exercise $1.75 35,361 61,882 9,343,776
4
Jul 06, 2017, 04:06 PM
Y! GHDX Director Jul 01, 2017 Option Exercise $32.55 3,684 119,914 11,359,826
4
Jul 05, 2017, 06:19 PM
Y! INCY Director Jun 30, 2017 Option Exercise $125.91 450 56,660 29,161,945
4
Jul 05, 2017, 06:01 PM
Y! ALXN Director Jun 15, 2017 Buy $117.33 656,387 77,012,514 7,645,906
4
Jun 16, 2017, 04:04 PM
Y! ALXN Director Jun 14, 2017 Buy $118.00 4,392 518,256 7,321,850
4
Jun 16, 2017, 04:04 PM
Y! ALXN Director Jun 14, 2017 Buy $116.32 1,348,955 156,915,230 7,317,906
4
Jun 16, 2017, 04:03 PM
Y! GHDX Director May 31, 2017 Option Exercise $18.13 49,500 897,435 11,359,212
4
Jun 01, 2017, 05:19 PM
Y! SGEN Director May 19, 2017 Option Exercise $66.60 3,700 246,420 40,898,792
4
May 23, 2017, 05:11 PM
Y! SGEN Director May 19, 2017 Option Exercise $66.60 3,700 246,420 4,888,564
4
May 23, 2017, 05:11 PM
Y! SGEN Director May 15, 2017 Option Exercise $10.20 20,000 204,000 40,895,092
4
May 17, 2017, 05:26 PM
Y! INCY Director Apr 27, 2017 Option Exercise $7.26 60,000 435,600 29,161,795
4
Apr 28, 2017, 05:10 PM
Y! IDRA Director Apr 03, 2017 Option Exercise $2.43 25,461 61,870 9,331,989
4
Apr 05, 2017, 04:59 PM
Y! INCY Director Mar 31, 2017 Option Exercise $133.67 426 56,943 29,141,795
4
Apr 04, 2017, 07:33 PM
Y! GHDX Director Apr 01, 2017 Option Exercise $31.49 3,804 119,788 11,350,962
4
Apr 04, 2017, 07:32 PM
Y! BLCM 10% Owner Mar 24, 2017 Buy $12.00 166,666 1,999,992 4,527,089
4
Mar 28, 2017, 05:05 PM
Y! AQXP 10% Owner Jan 09, 2017 Buy $17.18 398,062 6,836,813 9,764,459
4
Jan 09, 2017, 06:46 PM
Y! IDRA Director Jan 03, 2017 Option Exercise $1.50 42,507 63,761 9,323,502
4
Jan 05, 2017, 07:00 PM
Y! GHDX Director Jan 01, 2017 Option Exercise $29.39 4,080 119,911 11,350,328
4
Jan 04, 2017, 06:30 PM
Y! INCY Director Dec 30, 2016 Option Exercise $100.27 567 56,853 19,758,174
4
Jan 04, 2017, 06:01 PM
Y! BGNE Director Nov 18, 2016 Buy $32.00 1,760,495 56,335,840 3,317,977
4
Nov 21, 2016, 06:13 PM
Y! NVTA 10% Owner Nov 17, 2016 Buy $6.00 733,333 4,399,998 6,480,668
4
Nov 18, 2016, 04:36 PM
Y! SGEN Director Nov 08, 2016 Buy $59.46 326,300 19,403,299 40,885,092
4
Nov 09, 2016, 04:37 PM
Y! SGEN Director Nov 07, 2016 Buy $58.74 56,200 3,301,345 40,590,914
4
Nov 09, 2016, 04:37 PM
Y! SGEN Director Nov 03, 2016 Buy $56.43 198,433 11,196,763 40,540,247
4
Nov 03, 2016, 06:12 PM
Y! SGEN Director Nov 02, 2016 Buy $56.15 466,619 26,200,958 40,019,506
4
Nov 03, 2016, 06:11 PM
Y! SGEN Director Nov 01, 2016 Buy $54.46 184,674 10,057,349 39,598,943
4
Nov 03, 2016, 06:11 PM
Y! SGEN Director Nov 03, 2016 Buy $56.91 379,336 21,586,885 40,361,400
4
Nov 03, 2016, 06:11 PM
Y! IDRA Director Oct 07, 2016 Buy $2.00 3,250,000 6,500,000 9,309,333
4
Oct 11, 2016, 05:45 PM
Y! IDRA Director Oct 03, 2016 Option Exercise $2.56 24,897 63,736 6,380,737
4
Oct 05, 2016, 04:30 PM
Y! GHDX Director Sep 30, 2016 Option Exercise $28.92 4,140 119,729 11,349,648
4
Oct 04, 2016, 06:35 PM
Y! INCY Director Sep 30, 2016 Option Exercise $94.29 603 56,857 19,757,985
4
Oct 04, 2016, 06:33 PM
Y! AQXP 10% Owner Sep 20, 2016 Buy $12.25 2,783,605 34,110,452 9,404,467
4
Sep 21, 2016, 04:28 PM
Y! SGEN Director Sep 12, 2016 Buy $51.14 49,889 2,551,111 39,305,533
4
Sep 13, 2016, 06:05 PM
Y! SGEN Director Sep 09, 2016 Buy $50.42 256,220 12,917,842 39,260,675
4
Sep 13, 2016, 06:05 PM
Y! SGEN Director Sep 13, 2016 Buy $51.09 141,202 7,213,981 39,432,496
4
Sep 13, 2016, 06:05 PM
Y! SGEN Director Sep 06, 2016 Buy $45.90 143,363 6,580,527 4,643,343
4
Sep 08, 2016, 05:39 PM
Y! SGEN Director Sep 08, 2016 Buy $50.12 211,093 10,579,529 39,030,368
4
Sep 08, 2016, 05:39 PM
Y! SGEN Director Sep 07, 2016 Buy $48.52 59,560 2,889,689 38,840,624
4
Sep 08, 2016, 05:39 PM
Y! BCRX 10% Owner Aug 16, 2016 Sale $4.29 990 4,246 9,418,390
4
Aug 16, 2016, 06:11 PM
Y! BCRX 10% Owner Aug 15, 2016 Sale $4.83 400,000 1,931,040 9,419,240
4
Aug 16, 2016, 06:11 PM
Y! BCRX 10% Owner Aug 12, 2016 Sale $5.02 3,645,600 18,315,817 10,059,679
4
Aug 16, 2016, 06:11 PM
Y! GHDX Director Aug 15, 2016 Buy $27.02 100,000 2,701,590 11,348,958
4
Aug 15, 2016, 06:02 PM
Y! ACAD Director Aug 10, 2016 Buy $33.00 1,303,030 42,999,990 22,337,275
4
Aug 12, 2016, 04:08 PM
Y! GHDX Director Jul 01, 2016 Option Exercise $26.74 4,476 119,688 11,259,062
4
Jul 06, 2016, 06:22 PM
Y! IDRA Director Jul 01, 2016 Option Exercise $1.63 39,114 63,756 6,372,438
4
Jul 06, 2016, 06:21 PM
Y! INCY Director Jun 30, 2016 Option Exercise $79.98 711 56,866 19,757,784
4
Jul 05, 2016, 05:13 PM
Y! MRTX 10% Owner Jun 09, 2016 Sale $9.45 545,058 5,150,516 2,281,101
4
Jun 09, 2016, 05:06 PM
Y! MRTX 10% Owner Jun 08, 2016 Sale $9.21 158,100 1,456,481 2,631,020
4
Jun 09, 2016, 05:06 PM
Y! MRTX 10% Owner Jun 07, 2016 Sale $9.44 296,200 2,795,476 2,778,549
4
Jun 09, 2016, 05:06 PM
Y! SGEN Director May 20, 2016 Option Exercise $38.82 7,400 287,268 38,787,087
4
May 24, 2016, 05:50 PM
Y! GHDX Director May 17, 2016 Option Exercise $10.73 49,500 531,135 11,258,316
4
May 19, 2016, 06:23 PM
Y! NTLA Former 10% owner May 11, 2016 Buy $18.00 200,000 3,600,000 976,214
4
May 11, 2016, 04:25 PM
Y! IDRA Director Apr 01, 2016 Option Exercise $1.97 32,364 63,757 6,359,400
4
Apr 05, 2016, 06:00 PM
Y! GHDX Director Apr 01, 2016 Option Exercise $25.48 4,704 119,858 11,250,066
4
Apr 05, 2016, 05:58 PM
Y! INCY Director Mar 31, 2016 Option Exercise $72.47 786 56,961 19,757,547
4
Apr 04, 2016, 06:32 PM
Y! MRTX 10% Owner Mar 30, 2016 Option Exercise $6.74 313,482 2,112,869 3,054,055
4
Apr 01, 2016, 04:22 PM
Y! MRTX 10% Owner Mar 30, 2016 Option Exercise $6.74 274 1,847 137
4
Apr 01, 2016, 04:22 PM
Y! ACAD Director Apr 01, 2016 Buy $28.52 302,900 8,638,572 21,167,398
4
Apr 01, 2016, 04:21 PM
Y! ACAD Director Mar 31, 2016 Buy $27.21 683,644 18,601,181 20,894,327
4
Apr 01, 2016, 04:21 PM
Y! ACAD Director Mar 30, 2016 Buy $25.94 462,546 12,000,056 2,799,646
4
Apr 01, 2016, 04:21 PM
Y! SGEN Director Mar 17, 2016 Buy $31.85 124,065 3,951,304 38,783,387
4
Mar 21, 2016, 04:32 PM
Y! INCY Director Mar 17, 2016 Option Exercise $3.86 60,000 231,600 19,396,568
4
Mar 17, 2016, 07:14 PM
Y! INCY Director Mar 17, 2016 Buy $61.49 400,000 24,595,777 19,757,285
4
Mar 17, 2016, 07:14 PM
Y! INCY Director Mar 15, 2016 Buy $66.47 400,000 26,588,417 19,376,568
4
Mar 17, 2016, 07:14 PM
Y! SGEN Director Mar 15, 2016 Buy $32.08 661,093 21,210,834 38,158,204
4
Mar 16, 2016, 06:57 PM
Y! SGEN Director Mar 14, 2016 Buy $33.77 118,941 4,016,519 37,562,036
4
Mar 16, 2016, 06:57 PM
Y! SGEN Director Mar 16, 2016 Buy $31.77 569,203 18,084,599 38,671,506
4
Mar 16, 2016, 06:57 PM
Y! AQXP 10% Owner Mar 15, 2016 Buy $7.88 3,374 26,582 781,421
4
Mar 16, 2016, 06:56 PM
Y! AQXP 10% Owner Mar 16, 2016 Buy $8.00 361,755 2,893,570 6,928,119
4
Mar 16, 2016, 06:56 PM
Y! AQXP 10% Owner Mar 15, 2016 Buy $7.98 106,538 850,484 6,601,891
4
Mar 16, 2016, 06:56 PM
Y! SGEN Director Mar 11, 2016 Buy $33.10 195,765 6,480,738 37,454,776
4
Mar 11, 2016, 06:13 PM
Y! SGEN Director Mar 10, 2016 Buy $32.34 290,231 9,386,567 37,278,782
4
Mar 11, 2016, 06:13 PM
Y! SGEN Director Mar 09, 2016 Buy $32.03 208,670 6,683,985 37,017,863
4
Mar 11, 2016, 06:13 PM
Y! SGEN Director Mar 02, 2016 Buy $32.67 400,000 13,068,812 36,367,808
4
Mar 02, 2016, 06:31 PM
Y! SGEN Director Mar 01, 2016 Buy $31.24 24,200 756,112 36,007,250
4
Mar 02, 2016, 06:31 PM
Y! SGEN Director Feb 29, 2016 Buy $30.39 251,722 7,650,310 35,985,436
4
Mar 02, 2016, 06:31 PM
Y! SGEN Director Feb 26, 2016 Buy $30.13 44,300 1,334,945 35,758,535
4
Feb 26, 2016, 05:42 PM
Y! SGEN Director Feb 25, 2016 Buy $29.86 142,702 4,261,553 35,718,720
4
Feb 26, 2016, 05:42 PM
Y! SGEN Director Feb 24, 2016 Buy $28.99 127,506 3,696,568 35,590,465
4
Feb 26, 2016, 05:42 PM
Y! INCY Director Feb 24, 2016 Buy $70.41 57,590 4,055,187 19,009,830
4
Feb 26, 2016, 04:42 PM
Y! INCY Director Feb 25, 2016 Buy $74.00 6,700 495,800 19,015,852
4
Feb 26, 2016, 04:42 PM
Y! SGEN Director Feb 22, 2016 Buy $30.21 243,411 7,354,639 35,475,868
4
Feb 22, 2016, 05:34 PM
Y! SGEN Director Feb 19, 2016 Buy $29.20 506,526 14,790,560 35,257,100
4
Feb 22, 2016, 05:34 PM
Y! SGEN Director Feb 18, 2016 Buy $29.94 251,534 7,530,350 34,800,251
4
Feb 22, 2016, 05:34 PM
Y! SGEN Director Feb 16, 2016 Buy $29.80 270,163 8,049,663 33,847,095
4
Feb 17, 2016, 06:05 PM
Y! SGEN Director Feb 12, 2016 Buy $27.93 193,717 5,410,745 33,588,605
4
Feb 17, 2016, 06:05 PM
Y! SGEN Director Feb 17, 2016 Buy $31.25 805,267 25,161,937 34,573,386
4
Feb 17, 2016, 06:05 PM
Y! INCY Director Feb 16, 2016 Buy $70.71 678,488 47,973,375 18,958,070
4
Feb 16, 2016, 08:14 PM
Y! INCY Director Feb 12, 2016 Buy $67.14 208,677 14,010,425 18,346,124
4
Feb 16, 2016, 08:14 PM
Y! INCY Director Feb 12, 2016 Buy $65.83 922,530 60,732,037 18,158,080
4
Feb 16, 2016, 08:13 PM
Y! INCY Director Feb 11, 2016 Buy $61.93 1,328,897 82,297,659 17,326,770
4
Feb 16, 2016, 08:13 PM
Y! BGNE Director Feb 08, 2016 Buy $24.00 1,912,680 45,904,320 1,723,306
4
Feb 09, 2016, 05:38 PM
Y! BGNE Director Feb 08, 2016 Option Exercise $0.68 2,592,593 1,750,000 73,162,022
4
Feb 09, 2016, 05:38 PM
Y! BCRX 10% Owner Feb 05, 2016 Buy $6.33 45,000 284,656 12,894,240
4
Feb 09, 2016, 05:24 PM
Y! BCRX 10% Owner Feb 04, 2016 Buy $6.65 24,800 164,915 12,849,240
4
Feb 04, 2016, 05:15 PM
Y! BCRX 10% Owner Feb 03, 2016 Buy $6.29 91,187 573,311 12,824,440
4
Feb 04, 2016, 05:15 PM
Y! BCRX 10% Owner Feb 02, 2016 Buy $6.52 91,728 598,360 12,733,253
4
Feb 04, 2016, 05:15 PM
Y! BCRX 10% Owner Jan 28, 2016 Buy $6.88 25,000 172,015 12,641,525
4
Jan 29, 2016, 04:42 PM
Y! BCRX 10% Owner Jan 27, 2016 Buy $6.98 63,345 441,971 12,616,525
4
Jan 29, 2016, 04:42 PM
Y! AQXP 10% Owner Jan 22, 2016 Buy $10.72 50,315 539,465 6,422,989
4
Jan 26, 2016, 06:53 PM
Y! AQXP 10% Owner Jan 22, 2016 Buy $10.78 1,887 20,345 765,980
4
Jan 26, 2016, 06:53 PM
Y! AQXP 10% Owner Jan 26, 2016 Buy $10.81 77,639 839,524 6,502,773
4
Jan 26, 2016, 06:53 PM
Y! AQXP 10% Owner Jan 25, 2016 Buy $11.11 10,945 121,576 6,432,847
4
Jan 26, 2016, 06:53 PM
Y! BCRX 10% Owner Jan 22, 2016 Buy $7.00 3,200 22,389 12,553,180
4
Jan 25, 2016, 06:10 PM
Y! BCRX 10% Owner Jan 21, 2016 Buy $7.29 103,600 755,368 12,549,980
4
Jan 25, 2016, 06:10 PM
Y! BCRX 10% Owner Jan 20, 2016 Buy $6.87 52,695 362,171 12,446,380
4
Jan 20, 2016, 07:13 PM
Y! BCRX 10% Owner Jan 19, 2016 Buy $7.12 92,200 656,750 12,393,685
4
Jan 20, 2016, 07:13 PM
Y! BCRX 10% Owner Jan 15, 2016 Buy $7.46 200,000 1,491,222 12,301,485
4
Jan 20, 2016, 07:13 PM
Y! AQXP 10% Owner Jan 19, 2016 Buy $9.11 73,016 665,474 6,274,969
4
Jan 20, 2016, 07:12 PM
Y! AQXP 10% Owner Jan 19, 2016 Buy $9.08 5,029 45,642 750,354
4
Jan 20, 2016, 07:12 PM
Y! AQXP 10% Owner Jan 20, 2016 Buy $9.48 112,034 1,062,538 6,375,941
4
Jan 20, 2016, 07:12 PM
Y! AQXP 10% Owner Jan 15, 2016 Buy $8.47 84,670 717,201 6,204,630
4/A
Jan 15, 2016, 05:37 PM
Y! AQXP 10% Owner Jan 14, 2016 Buy $8.13 107,983 878,410 6,128,358
4/A
Jan 15, 2016, 05:37 PM
Y! AQXP 10% Owner Jan 14, 2016 Buy $8.17 9,970 81,472 735,198
4/A
Jan 15, 2016, 05:37 PM
Y! AQXP 10% Owner Jan 14, 2016 Buy $8.17 9,970 81,472 735,198
4
Jan 15, 2016, 05:13 PM
Y! AQXP 10% Owner Jan 15, 2016 Buy $8.47 84,670 717,201 6,204,630
4
Jan 15, 2016, 05:13 PM
Y! AQXP 10% Owner Jan 14, 2016 Buy $8.13 107,983 878,410 6,128,358
4
Jan 15, 2016, 05:13 PM
Y! ACAD Director Jan 07, 2016 Buy $29.00 2,586,206 74,999,974 20,278,008
4/A
Jan 08, 2016, 07:07 PM
Y! ACAD Director Jan 07, 2016 Buy $29.00 2,586,206 74,999,974 20,278,008
4
Jan 08, 2016, 06:07 PM
Y! IDRA Director Jan 04, 2016 Option Exercise $3.00 21,246 63,738 6,348,612
4
Jan 06, 2016, 06:02 PM
Y! GHDX Director Jan 01, 2016 Option Exercise $35.20 3,408 119,962 11,249,282
4
Jan 05, 2016, 06:47 PM
Y! SGEN Director Nov 20, 2015 Buy $43.98 181,647 7,988,259 33,428,852
4
Nov 20, 2015, 05:02 PM
Y! SGEN Director Nov 19, 2015 Buy $43.93 133,073 5,845,378 33,247,205
4
Nov 20, 2015, 05:02 PM
Y! SGEN Director Nov 18, 2015 Buy $43.61 14,638 638,321 33,114,132
4
Nov 20, 2015, 05:02 PM
Y! SGEN Director Nov 09, 2015 Buy $43.76 507,300 22,200,588 33,090,094
4
Nov 10, 2015, 07:57 PM
Y! SGEN Director Nov 06, 2015 Buy $41.94 417,924 17,529,497 32,582,794
4
Nov 10, 2015, 07:57 PM
Y! SGEN Director Nov 10, 2015 Buy $44.00 9,400 413,600 33,099,494
4
Nov 10, 2015, 07:57 PM
Y! GHDX Director Oct 01, 2015 Option Exercise $21.34 5,616 119,845 11,248,714
4
Oct 05, 2015, 07:17 PM
Y! INCY Director Oct 01, 2015 Option Exercise $110.33 516 56,930 16,129,099
4
Oct 05, 2015, 07:04 PM
Y! IDRA Director Oct 01, 2015 Option Exercise $3.06 20,835 63,755 6,341,530
4
Oct 05, 2015, 06:59 PM
Y! MRTX 10% Owner Sep 16, 2015 Buy $45.00 150,000 6,750,000 2,744,052
4
Sep 16, 2015, 06:25 PM
Y! SGEN Director Sep 11, 2015 Buy $41.43 4,212,787 174,517,109 31,218,173
4
Sep 15, 2015, 07:04 PM
Y! SGEN Director Sep 15, 2015 Buy $48.28 626,259 30,237,807 32,164,870
4
Sep 15, 2015, 07:04 PM
Y! SGEN Director Sep 14, 2015 Buy $46.34 320,438 14,849,199 31,538,611
4
Sep 15, 2015, 07:04 PM
Y! AQXP 10% Owner Sep 10, 2015 Buy $15.50 2,213,469 34,308,770 6,022,104
4
Sep 11, 2015, 04:11 PM
Y! AQXP 10% Owner Sep 10, 2015 Buy $15.50 266,563 4,131,727 725,228
4
Sep 11, 2015, 04:11 PM
Y! XOMA Former 10% owner Jul 22, 2015 Sale $1.09 11,000,000 12,017,500 3,153,539
4
Jul 23, 2015, 05:35 PM
Y! GHDX Director Jul 01, 2015 Option Exercise $27.34 4,380 119,749 11,247,778
4
Jul 06, 2015, 05:42 PM
Y! INCY Director Jul 01, 2015 Option Exercise $104.21 546 56,899 12,485,965
4
Jul 06, 2015, 05:40 PM
Y! SGEN Director May 19, 2015 Buy $40.87 214,129 8,751,249 26,268,629
4
May 21, 2015, 07:42 PM
Y! SGEN Director May 21, 2015 Buy $43.38 362,459 15,723,084 27,005,386
4
May 21, 2015, 07:42 PM
Y! SGEN Director May 20, 2015 Buy $42.56 374,298 15,929,272 26,652,609
4
May 21, 2015, 07:42 PM
Y! SGEN Director May 15, 2015 Option Exercise $39.94 7,400 295,556 26,054,500
4
May 18, 2015, 06:45 PM
Y! INCY Director May 11, 2015 Option Exercise $7.68 60,000 460,800 12,485,783
4
May 12, 2015, 06:58 PM
Y! SGEN Director May 11, 2015 Option Exercise $5.11 20,000 102,200 26,050,800
4
May 12, 2015, 09:04 AM
Y! SGEN Director May 07, 2015 Buy $37.15 47,717 1,772,790 26,040,800
4
May 07, 2015, 09:32 PM
Y! SGEN Director May 06, 2015 Buy $36.41 453,995 16,530,995 25,993,083
4
May 07, 2015, 09:32 PM
Y! SGEN Director May 05, 2015 Buy $34.69 530,952 18,419,925 25,539,088
4
May 07, 2015, 09:32 PM
Y! IDRA Director Apr 01, 2015 Option Exercise $3.52 16,410 57,763 6,329,325
4
Apr 02, 2015, 07:09 PM
Y! GHDX Director Apr 01, 2015 Option Exercise $30.43 3,936 119,772 11,247,048
4
Apr 02, 2015, 06:37 PM
Y! SGEN Director Mar 10, 2015 Buy $34.54 9,319 321,921 25,008,136
4
Mar 11, 2015, 06:55 PM
Y! SGEN Director Mar 09, 2015 Buy $34.66 275,717 9,556,609 24,998,817
4
Mar 11, 2015, 06:55 PM
Y! SGEN Director Feb 24, 2015 Buy $33.76 217,465 7,341,491 24,210,609
4
Feb 26, 2015, 07:12 PM
Y! SGEN Director Feb 25, 2015 Buy $34.48 63,650 2,194,758 24,274,259
4
Feb 26, 2015, 07:12 PM
Y! IDRA Director Feb 13, 2015 Buy $3.75 5,333,333 19,999,999 6,323,855
4
Feb 17, 2015, 07:39 AM
Y! MRTX 10% Owner Jan 29, 2015 Buy $20.00 425,000 8,500,000 2,604,832
4
Feb 02, 2015, 05:33 PM
Y! GEVA Director Jan 07, 2015 Buy $94.19 1,000,000 94,190,002 9,184,771
4
Jan 09, 2015, 05:28 PM
Y! IDRA Director Jan 02, 2015 Option Exercise $4.90 11,781 57,727 1,425,446
4
Jan 06, 2015, 08:32 PM
Y! XOMA Director Jan 06, 2015 Sale $3.86 1,000,000 3,860,000 12,589,950
4
Jan 06, 2015, 08:31 PM
Y! XOMA Director Jan 05, 2015 Sale $3.81 1,003,300 3,824,078 13,449,938
4
Jan 06, 2015, 08:31 PM
Y! XOMA Director Jan 02, 2015 Sale $3.55 212,100 753,740 14,313,038
4
Jan 06, 2015, 08:31 PM
Y! XOMA Director Dec 30, 2014 Sale $3.65 391,900 1,430,239 14,495,492
4
Dec 30, 2014, 05:40 PM
Y! XOMA Director Dec 29, 2014 Sale $3.68 221,000 812,440 14,832,615
4
Dec 30, 2014, 05:40 PM
Y! XOMA Director Dec 26, 2014 Sale $3.71 131,100 486,460 15,022,732
4
Dec 30, 2014, 05:40 PM
Y! XOMA Director Dec 18, 2014 Sale $4.29 165,700 710,687 15,783,368
4
Dec 19, 2014, 05:13 PM
Y! XOMA Director Dec 17, 2014 Sale $4.31 686,500 2,958,129 15,925,911
4
Dec 19, 2014, 05:13 PM
Y! XOMA Director Dec 19, 2014 Sale $4.21 752,900 3,168,580 15,135,587
4
Dec 19, 2014, 05:13 PM
Y! XOMA Director Dec 12, 2014 Sale $4.71 253,800 1,196,413 17,187,779
4
Dec 16, 2014, 05:29 PM
Y! XOMA Director Dec 16, 2014 Sale $4.27 319,200 1,363,271 16,516,549
4
Dec 16, 2014, 05:29 PM
Y! XOMA Director Dec 15, 2014 Sale $4.45 460,800 2,050,652 16,791,283
4
Dec 16, 2014, 05:29 PM
Y! SGEN Director Dec 10, 2014 Buy $34.40 654,150 22,501,700 21,109,766
4
Dec 10, 2014, 08:04 PM
Y! SGEN Director Dec 09, 2014 Buy $34.16 128,430 4,387,345 20,455,616
4
Dec 10, 2014, 08:04 PM
Y! SGEN Director Dec 08, 2014 Buy $32.93 465,316 15,320,685 20,327,186
4
Dec 10, 2014, 08:04 PM
Y! XOMA Director Dec 09, 2014 Sale $4.62 392,353 1,811,062 17,406,162
4
Dec 10, 2014, 05:50 PM
Y! XOMA Director Dec 04, 2014 Sale $4.55 1,304,288 5,928,902 17,743,703
4
Dec 04, 2014, 06:05 PM
Y! XOMA Director Dec 03, 2014 Sale $4.84 567,918 2,748,837 18,866,287
4
Dec 04, 2014, 06:05 PM
Y! XOMA Director Dec 02, 2014 Sale $5.36 500,000 2,679,550 19,353,087
4
Dec 04, 2014, 06:05 PM
Y! IDRA Director Oct 01, 2014 Option Exercise $2.16 26,742 57,763 1,421,519
4
Oct 03, 2014, 05:55 PM
Y! GHDX Director Jul 01, 2014 Option Exercise $27.86 4,296 119,687 11,245,068
4
Jul 03, 2014, 02:33 PM
Y! GEVA Director Jun 20, 2014 Option Exercise $60.45 29,750 1,798,388 8,184,771
4
Jun 24, 2014, 04:12 PM
Y! SGEN Director Jun 12, 2014 Buy $39.94 128,008 5,112,199 18,121,499
4
Jun 16, 2014, 04:33 PM
Y! SGEN Director Jun 13, 2014 Buy $39.89 88,587 3,533,526 18,207,945
4
Jun 16, 2014, 04:33 PM
Y! SGEN Director Jun 09, 2014 Buy $38.92 251,093 9,772,651 17,996,584
4
Jun 09, 2014, 05:26 PM
Y! SGEN Director Jun 06, 2014 Buy $37.41 174,987 6,546,471 17,751,559
4
Jun 09, 2014, 05:26 PM
Y! SGEN Director Jun 05, 2014 Buy $37.67 120,172 4,526,317 17,580,806
4
Jun 09, 2014, 05:26 PM
Y! SGEN Director Jun 04, 2014 Buy $36.13 87,042 3,145,161 17,463,541
4
Jun 04, 2014, 07:27 PM
Y! SGEN Director Jun 03, 2014 Buy $34.47 100,304 3,457,722 17,378,605
4
Jun 04, 2014, 07:27 PM
Y! SGEN Director Jun 02, 2014 Buy $34.09 94,617 3,225,210 17,280,727
4
Jun 04, 2014, 07:27 PM
Y! INCY Director May 21, 2014 Option Exercise $7.02 30,000 210,600 12,465,783
4
May 23, 2014, 05:07 PM
Y! SGEN Director May 14, 2014 Option Exercise $7.26 30,000 217,800 16,999,872
4
May 16, 2014, 07:00 PM
Y! SGEN Director May 16, 2014 Buy $34.05 168,411 5,734,196 17,188,399
4
May 16, 2014, 07:00 PM
Y! SGEN Director May 15, 2014 Buy $34.26 21,200 726,356 17,020,560
4
May 16, 2014, 07:00 PM
Y! SGEN Director May 08, 2014 Buy $34.02 233,055 7,929,305 16,855,137
4/A
May 16, 2014, 04:52 PM
Y! SGEN Director May 07, 2014 Buy $33.59 117,254 3,938,140 16,627,717
4/A
May 16, 2014, 04:52 PM
Y! SGEN Director May 09, 2014 Buy $34.16 138,073 4,715,922 16,989,872
4/A
May 16, 2014, 04:52 PM
Y! SGEN Director May 07, 2013 Buy $33.59 117,254 3,938,140 16,627,717
4
May 09, 2014, 05:16 PM
Y! SGEN Director May 09, 2013 Buy $34.16 138,073 4,715,922 16,989,872
4
May 09, 2014, 05:16 PM
Y! SGEN Director May 08, 2013 Buy $34.02 233,055 7,929,305 16,855,137
4
May 09, 2014, 05:16 PM
Y! GEVA Director Apr 23, 2014 Option Exercise $65.10 56,000 3,645,600 8,180,521
4
Apr 25, 2014, 08:04 PM
Y! GHDX Director Apr 01, 2014 Option Exercise $26.57 4,512 119,884 11,244,352
4
Apr 03, 2014, 07:22 PM
Y! GEVA Director Mar 06, 2014 Buy $105.75 375,000 39,656,250 8,172,521
4
Mar 07, 2014, 05:54 PM
Y! ACAD Director Mar 05, 2014 Buy $28.50 526,316 15,000,006 18,476,847
4
Mar 07, 2014, 05:27 PM
Y! GHDX Director Jan 01, 2014 Option Exercise $29.27 4,092 119,773 11,243,600
4
Jan 03, 2014, 05:29 PM
Y! SGEN Director Dec 12, 2013 Buy $39.59 284,610 11,268,201 16,393,812
4
Dec 16, 2013, 07:42 PM
Y! SGEN Director Dec 16, 2013 Buy $39.92 78,759 3,143,952 16,513,298
4
Dec 16, 2013, 07:42 PM
Y! SGEN Director Dec 13, 2013 Buy $39.65 43,709 1,733,276 16,436,458
4
Dec 16, 2013, 07:42 PM
Y! SGEN Director Dec 05, 2013 Buy $44.00 365,676 16,089,489 16,116,121
4
Dec 05, 2013, 08:13 PM
Y! SGEN Director Dec 04, 2013 Buy $43.11 270,795 11,675,184 15,759,353
4
Dec 05, 2013, 08:13 PM
Y! SGEN Director Dec 03, 2013 Buy $42.44 369,430 15,678,059 15,495,154
4
Dec 05, 2013, 08:13 PM
Y! MRTX 10% Owner Oct 24, 2013 Buy $17.50 400,000 7,000,000 2,213,897
4
Oct 28, 2013, 08:15 PM
Y! GHDX Director Oct 01, 2013 Option Exercise $30.33 3,948 119,743 11,242,918
4
Oct 02, 2013, 05:27 PM
Y! XOMA Director Aug 19, 2013 Buy $3.62 2,757,791 9,983,203 19,767,770
4/A
Aug 21, 2013, 07:54 PM
Y! XOMA Director Aug 19, 2013 Option Exercise $3.62 2,757,791 9,983,203 19,767,770
4
Aug 21, 2013, 05:07 PM
Y! BCRX 10% Owner Aug 01, 2013 Buy $4.40 1,136,364 5,000,002 4,832,285
4
Aug 02, 2013, 04:00 PM
Y! GHDX Director Jul 01, 2013 Option Exercise $32.85 3,636 119,443 11,242,260
4
Jul 03, 2013, 05:25 PM
Y! INCY Director Jun 11, 2013 Option Exercise $4.44 30,000 133,200 12,455,783
4
Jun 13, 2013, 06:49 PM
Y! ACAD Director Jun 04, 2013 Buy $14.45 699,776 10,110,693 17,240,358
4
Jun 05, 2013, 06:47 PM
Y! ACAD Director Jun 03, 2013 Buy $14.06 767,953 10,794,614 16,630,193
4
Jun 05, 2013, 06:47 PM
Y! ACAD Director Jun 05, 2013 Buy $14.51 872,585 12,657,999 18,001,203
4
Jun 05, 2013, 06:47 PM
Y! GHDX Director Jun 04, 2013 Buy $36.62 163,659 5,993,192 11,051,768
4
Jun 05, 2013, 05:23 PM
Y! GHDX Director Jun 05, 2013 Buy $35.81 194,621 6,970,351 11,241,654
4
Jun 05, 2013, 05:23 PM
Y! GHDX Director Jun 05, 2013 Buy $35.81 23,152 829,189 1,730,777
4
Jun 05, 2013, 05:23 PM
Y! GHDX Director May 29, 2013 Buy $36.82 41,954 1,544,813 10,752,532
4
May 29, 2013, 06:06 PM
Y! GHDX Director May 29, 2013 Buy $36.82 5,046 185,802 1,671,081
4
May 29, 2013, 06:06 PM
Y! GHDX Director May 28, 2013 Buy $36.93 74,266 2,742,933 10,711,599
4
May 29, 2013, 06:06 PM
Y! GHDX Director May 24, 2013 Buy $36.93 62,517 2,308,909 10,646,920
4
May 24, 2013, 05:04 PM
Y! GHDX Director May 23, 2013 Buy $36.99 13,645 504,693 10,592,521
4
May 24, 2013, 05:04 PM
Y! GHDX Director May 23, 2013 Buy $36.59 3,255 119,106 10,579,208
4
May 24, 2013, 05:04 PM
Y! ACAD Director May 15, 2013 Buy $12.50 1,993,000 24,912,500 15,960,582
4
May 17, 2013, 04:10 PM
Y! GHDX Director May 16, 2013 Buy $36.54 17,186 627,963 10,577,816
4
May 16, 2013, 06:03 PM
Y! GHDX Director May 16, 2013 Buy $36.54 2,120 77,463 1,649,473
4
May 16, 2013, 06:03 PM
Y! GHDX Director May 15, 2013 Buy $36.41 52,133 1,898,361 10,561,048
4
May 16, 2013, 06:03 PM
Y! GHDX Director May 13, 2013 Buy $34.02 144,478 4,914,910 10,492,159
4
May 14, 2013, 06:40 PM
Y! GHDX Director May 13, 2013 Buy $34.56 68,764 2,376,256 10,351,197
4
May 14, 2013, 06:40 PM
Y! GHDX Director May 14, 2013 Buy $35.53 27,184 965,899 10,515,769
4
May 14, 2013, 06:40 PM
Y! GHDX Director Apr 01, 2013 Option Exercise $27.99 4,284 119,909 10,306,953
4
Apr 03, 2013, 05:50 PM
Y! GHDX Director Feb 21, 2013 Buy $27.64 3,080 85,122 1,614,513
4
Feb 21, 2013, 06:11 PM
Y! GHDX Director Feb 20, 2013 Buy $27.97 20,885 584,220 10,281,731
4
Feb 21, 2013, 06:11 PM
Y! GHDX Director Feb 21, 2013 Buy $27.64 25,120 694,237 10,306,239
4
Feb 21, 2013, 06:11 PM
Y! GHDX Director Feb 13, 2013 Buy $28.58 17,200 491,585 10,233,478
4
Feb 14, 2013, 05:51 PM
Y! GHDX Director Feb 14, 2013 Buy $28.43 30,860 877,384 10,263,580
4
Feb 14, 2013, 05:51 PM
Y! GHDX Director Feb 14, 2013 Buy $28.43 3,940 112,019 1,609,152
4
Feb 14, 2013, 05:51 PM
Y! GHDX Director Feb 11, 2013 Buy $28.23 70,929 2,002,446 10,218,600
4
Feb 11, 2013, 06:43 PM
Y! GHDX Director Feb 11, 2013 Buy $28.23 9,055 255,638 1,603,265
4
Feb 11, 2013, 06:43 PM
Y! GHDX Director Feb 08, 2013 Buy $27.96 36,376 1,017,106 10,149,413
4
Feb 11, 2013, 06:43 PM
Y! GEVA Director Jan 04, 2013 Buy $47.53 859,720 40,862,491 6,782,215
4
Jan 08, 2013, 05:40 PM
Y! GHDX Director Nov 21, 2012 Buy $27.54 300 8,262 10,117,174
4
Nov 23, 2012, 01:24 PM
Y! GHDX Director Nov 20, 2012 Buy $26.83 229,000 6,143,360 10,116,906
4
Nov 23, 2012, 01:24 PM
Y! XOMA Director Oct 29, 2012 Buy $3.00 4,722,666 14,167,998 17,888,512
4
Oct 31, 2012, 05:02 PM
Y! GEVA Director Jul 13, 2012 Buy $41.20 886,000 36,503,201 5,942,594
4
Jul 13, 2012, 06:59 PM
Y! RDEA Director Jun 19, 2012 Option Exercise $32.00 6,914,291 221,257,312 0
4
Jun 21, 2012, 04:13 PM
Y! GHDX Director May 22, 2012 Buy $32.94 17,406 573,401 9,086,690
4
May 23, 2012, 05:03 PM
Y! GHDX Director May 21, 2012 Buy $32.18 150,000 4,826,972 9,069,664
4
May 23, 2012, 05:03 PM
Y! GHDX Director May 16, 2012 Buy $34.46 23,621 813,925 8,922,942
4
May 16, 2012, 08:18 PM
Y! GHDX Director May 15, 2012 Buy $34.09 140,000 4,772,474 8,899,838
4
May 16, 2012, 08:18 PM
Y! GHDX Director May 14, 2012 Buy $33.68 212,438 7,153,896 8,762,905
4
May 16, 2012, 08:18 PM
Y! GHDX Director May 10, 2012 Buy $29.87 68,681 2,051,783 8,529,088
4
May 11, 2012, 06:01 PM
Y! GHDX Director May 09, 2012 Buy $29.90 19,547 584,367 8,462,023
4
May 11, 2012, 06:01 PM
Y! GHDX Director May 11, 2012 Buy $30.22 26,660 805,567 8,555,121
4
May 11, 2012, 06:01 PM
Y! GHDX Director May 04, 2012 Buy $28.02 53,128 1,488,643 8,305,414
4
May 08, 2012, 07:00 PM
Y! GHDX Director May 08, 2012 Buy $28.83 86,033 2,480,619 8,442,936
4
May 08, 2012, 07:00 PM
Y! GHDX Director May 07, 2012 Buy $28.26 56,540 1,597,965 8,358,928
4
May 08, 2012, 07:00 PM