| Owner |
Relationship |
Date |
Transaction |
Cost |
# Shares |
Value($) |
Total Shares |
Form |
Form 4 |
| Hung David |
President and CEO |
Apr 23 |
Sale |
$55.00 |
1,615 |
88,825 |
1,862,480 |
4 |
Apr 25, 05:48 PM |
| Hung David |
President and CEO |
Apr 19 |
Sale |
$55.13 |
57,465 |
3,168,247 |
1,873,930 |
4 |
Apr 22, 04:43 PM |
| Hung David |
President and CEO |
Apr 18 |
Sale |
$55.00 |
200 |
11,000 |
1,931,395 |
4 |
Apr 22, 04:43 PM |
| Hung David |
President and CEO |
Apr 22 |
Sale |
$55.02 |
9,835 |
541,156 |
1,864,095 |
4 |
Apr 22, 04:43 PM |
| Hung David |
President and CEO |
Apr 11 |
Sale |
$52.62 |
50,000 |
2,631,030 |
1,931,595 |
4 |
Apr 15, 05:03 PM |
| Hung David |
President and CEO |
Apr 05 |
Sale |
$50.17 |
50,000 |
2,508,500 |
1,981,595 |
4 |
Apr 09, 06:06 PM |
| VERNON W ANTHONY |
Director |
Mar 15 |
Option Exercise |
$8.17 |
60,000 |
490,200 |
66,832 |
4 |
Mar 19, 05:19 PM |
| VERNON W ANTHONY |
Director |
Mar 15 |
Sale |
$45.91 |
60,000 |
2,754,600 |
6,832 |
4 |
Mar 19, 05:19 PM |
| BLICKENSTAFF KIM D |
Director |
Mar 07 |
Option Exercise |
$9.38 |
60,000 |
562,500 |
60,000 |
4 |
Mar 11, 05:06 PM |
| BLICKENSTAFF KIM D |
Director |
Mar 08 |
Sale |
$47.21 |
44,800 |
2,114,976 |
13,500 |
4 |
Mar 11, 05:06 PM |
| BLICKENSTAFF KIM D |
Director |
Mar 07 |
Sale |
$46.18 |
15,200 |
701,936 |
44,800 |
4 |
Mar 11, 05:06 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
Dec 10 |
Option Exercise |
$54.40 |
5,125 |
278,825 |
43,084 |
4 |
Dec 11, 07:00 PM |
| Hung David |
President and CEO |
Dec 10 |
Sale |
$54.42 |
10,246 |
557,553 |
2,036,910 |
4 |
Dec 11, 06:58 PM |
| Bailey Gregory |
Director |
Oct 30 |
Option Exercise |
$5.68 |
243,771 |
1,384,869 |
691,101 |
4 |
Nov 01, 08:32 PM |
| Bailey Gregory |
Director |
Oct 24 |
Sale |
$53.60 |
16,800 |
900,480 |
447,330 |
4 |
Oct 26, 04:30 PM |
| Bailey Gregory |
Director |
Oct 16 |
Sale |
$53.50 |
3,200 |
171,200 |
464,130 |
4 |
Oct 18, 04:55 PM |
| Bailey Gregory |
Director |
Oct 05 |
Sale |
$58.42 |
20,000 |
1,168,400 |
467,330 |
4 |
Oct 09, 05:37 PM |
| Bailey Gregory |
Director |
Oct 04 |
Sale |
$57.77 |
20,000 |
1,155,400 |
487,330 |
4 |
Oct 09, 05:37 PM |
| Hung David |
President and CEO |
Oct 04 |
Sale |
$57.92 |
50,000 |
2,895,780 |
2,010,841 |
4 |
Oct 05, 04:40 PM |
| Hung David |
President and CEO |
Sep 28 |
Option Exercise |
$56.35 |
17,707 |
997,789 |
2,060,841 |
4/A |
Oct 03, 04:53 PM |
| Cohen Cheryl |
Chief Commercial Officer |
Sep 28 |
Option Exercise |
$56.35 |
4,361 |
245,742 |
16,439 |
4/A |
Oct 03, 04:52 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
Sep 28 |
Option Exercise |
$56.35 |
6,473 |
364,754 |
36,549 |
4/A |
Oct 03, 04:52 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
Sep 28 |
Option Exercise |
$56.35 |
6,473 |
364,754 |
15,038 |
4 |
Oct 02, 05:39 PM |
| Cohen Cheryl |
Chief Commercial Officer |
Sep 28 |
Option Exercise |
$56.35 |
4,361 |
245,742 |
6,039 |
4 |
Oct 02, 05:38 PM |
| Hung David |
President and CEO |
Sep 28 |
Option Exercise |
$56.35 |
17,707 |
997,789 |
1,021,567 |
4 |
Oct 02, 05:37 PM |
| Bailey Gregory |
Director |
Sep 25 |
Sale |
$54.78 |
10,000 |
547,800 |
587,330 |
4 |
Sep 27, 06:44 PM |
| Bailey Gregory |
Director |
Sep 27 |
Sale |
$56.20 |
50,000 |
2,810,200 |
557,330 |
4 |
Sep 27, 06:44 PM |
| Adams Daniel |
Director |
Sep 25 |
Option Exercise |
$6.97 |
5,000 |
34,850 |
5,000 |
4 |
Sep 27, 06:43 PM |
| Adams Daniel |
Director |
Sep 27 |
Option Exercise |
$8.71 |
83,038 |
723,375 |
83,038 |
4 |
Sep 27, 06:43 PM |
| Adams Daniel |
Director |
Sep 27 |
Sale |
$55.73 |
83,038 |
4,627,749 |
0 |
4 |
Sep 27, 06:43 PM |
| Adams Daniel |
Director |
Sep 25 |
Sale |
$55.00 |
5,000 |
275,009 |
0 |
4 |
Sep 27, 06:43 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
Sep 07 |
Option Exercise |
$11.76 |
20,000 |
235,200 |
41,511 |
4 |
Sep 11, 04:53 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
Sep 07 |
Sale |
$105.74 |
20,000 |
2,114,858 |
28,111 |
4 |
Sep 11, 04:53 PM |
| Bailey Gregory |
Director |
Sep 06 |
Sale |
$108.24 |
28,606 |
3,096,402 |
316,655 |
4 |
Sep 10, 05:57 PM |
| Bailey Gregory |
Director |
Sep 07 |
Sale |
$108.02 |
1,550 |
167,433 |
299,772 |
4 |
Sep 10, 05:57 PM |
| Hung David |
President and CEO |
Sep 04 |
Sale |
$111.16 |
25,000 |
2,779,009 |
1,061,774 |
4 |
Sep 05, 05:51 PM |
| Seely Lynn |
Chief Medical Officer |
Jul 25 |
Option Exercise |
$34.56 |
2,400 |
82,944 |
23,911 |
4 |
Jul 27, 04:41 PM |
| Seely Lynn |
Chief Medical Officer |
Jul 26 |
Option Exercise |
$34.56 |
37,600 |
1,299,456 |
59,111 |
4 |
Jul 27, 04:41 PM |
| Seely Lynn |
Chief Medical Officer |
Jul 25 |
Sale |
$98.01 |
2,400 |
235,218 |
21,511 |
4 |
Jul 27, 04:41 PM |
| Seely Lynn |
Chief Medical Officer |
Jul 26 |
Sale |
$99.73 |
37,600 |
3,749,816 |
27,017 |
4 |
Jul 27, 04:41 PM |
| Hung David |
President and CEO |
Jul 03 |
Sale |
$95.05 |
25,000 |
2,376,205 |
1,064,274 |
4 |
Jul 09, 05:04 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
Jul 02 |
Option Exercise |
$11.76 |
10,000 |
117,600 |
31,511 |
4 |
Jul 05, 06:05 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
Jul 02 |
Sale |
$94.11 |
10,000 |
941,100 |
21,511 |
4 |
Jul 05, 06:05 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
May 22 |
Option Exercise |
$11.76 |
600 |
7,056 |
22,111 |
4 |
May 24, 07:13 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
May 24 |
Option Exercise |
$11.76 |
9,400 |
110,544 |
30,911 |
4 |
May 24, 07:13 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
May 24 |
Sale |
$89.17 |
9,400 |
838,213 |
21,511 |
4 |
May 24, 07:13 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
May 22 |
Sale |
$89.16 |
600 |
53,496 |
21,511 |
4 |
May 24, 07:13 PM |
| Seely Lynn |
Chief Medical Officer |
May 22 |
Option Exercise |
$13.47 |
12,500 |
168,375 |
34,011 |
4 |
May 24, 07:12 PM |
| Seely Lynn |
Chief Medical Officer |
May 22 |
Sale |
$88.51 |
12,500 |
1,106,334 |
21,511 |
4 |
May 24, 07:12 PM |
| Seely Lynn |
Chief Medical Officer |
May 17 |
Option Exercise |
$21.17 |
14,360 |
304,001 |
35,871 |
4 |
May 21, 04:27 PM |
| Seely Lynn |
Chief Medical Officer |
May 17 |
Sale |
$88.01 |
14,360 |
1,263,829 |
21,511 |
4 |
May 21, 04:27 PM |
| Seely Lynn |
Chief Medical Officer |
May 14 |
Option Exercise |
$21.17 |
35,640 |
754,499 |
57,151 |
4 |
May 16, 05:28 PM |
| Seely Lynn |
Chief Medical Officer |
May 14 |
Sale |
$88.08 |
35,640 |
3,139,029 |
21,511 |
4 |
May 16, 05:28 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
Apr 27 |
Option Exercise |
$11.76 |
10,000 |
117,600 |
31,511 |
4 |
May 01, 05:08 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
Apr 27 |
Sale |
$80.16 |
10,000 |
801,630 |
21,511 |
4 |
May 01, 05:08 PM |
| Seely Lynn |
Chief Medical Officer |
Mar 08 |
Option Exercise |
$73.01 |
40,000 |
2,920,314 |
40,281 |
4 |
Mar 12, 05:12 PM |
| Seely Lynn |
Chief Medical Officer |
Mar 08 |
Option Exercise |
$9.32 |
106,000 |
988,400 |
133,066 |
4 |
Mar 12, 05:12 PM |
| Seely Lynn |
Chief Medical Officer |
Mar 08 |
Sale |
$70.11 |
71,555 |
5,016,647 |
79,783 |
4 |
Mar 12, 05:12 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
Mar 08 |
Option Exercise |
$11.76 |
10,000 |
117,600 |
31,511 |
4 |
Mar 12, 05:11 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
Mar 08 |
Sale |
$75.10 |
10,000 |
751,000 |
21,511 |
4 |
Mar 12, 05:11 PM |
| Hung David |
President and CEO |
Feb 08 |
Sale |
$69.06 |
56,529 |
3,903,693 |
1,148,803 |
4 |
Feb 09, 06:55 PM |
| Hung David |
President and CEO |
Feb 07 |
Sale |
$71.68 |
43,471 |
3,115,795 |
1,209,474 |
4 |
Feb 09, 06:55 PM |
| BLICKENSTAFF KIM D |
Director |
Feb 08 |
Option Exercise |
$3.75 |
6,300 |
23,625 |
6,300 |
4 |
Feb 09, 06:55 PM |
| BLICKENSTAFF KIM D |
Director |
Feb 07 |
Option Exercise |
$3.75 |
13,700 |
51,375 |
13,700 |
4 |
Feb 09, 06:55 PM |
| BLICKENSTAFF KIM D |
Director |
Feb 08 |
Sale |
$69.19 |
6,300 |
435,926 |
4,100 |
4 |
Feb 09, 06:55 PM |
| BLICKENSTAFF KIM D |
Director |
Feb 07 |
Sale |
$71.62 |
13,700 |
981,201 |
12,600 |
4 |
Feb 09, 06:55 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
Feb 08 |
Option Exercise |
$11.76 |
19,193 |
225,710 |
57,093 |
4 |
Feb 09, 06:54 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
Feb 07 |
Option Exercise |
$11.76 |
16,391 |
192,758 |
80,807 |
4 |
Feb 09, 06:54 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
Feb 08 |
Sale |
$69.06 |
57,093 |
3,942,916 |
37,193 |
4 |
Feb 09, 06:54 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
Feb 07 |
Sale |
$71.68 |
42,907 |
3,075,416 |
76,307 |
4 |
Feb 09, 06:54 PM |
| Bailey Gregory |
Director |
Nov 09 |
Buy |
$40.80 |
3,000 |
122,399 |
347,321 |
4 |
Nov 14, 06:12 PM |
| QVT Associates GP LLC |
10% Owner |
Jun 07 |
Sale |
$22.62 |
368,147 |
8,329,089 |
3,595,791 |
4 |
Jun 09, 05:01 PM |
| QVT Associates GP LLC |
10% Owner |
Jun 02 |
Sale |
$22.84 |
50,752 |
1,158,930 |
3,943,531 |
4 |
Jun 06, 07:30 PM |
| QVT Associates GP LLC |
10% Owner |
Jun 06 |
Sale |
$22.21 |
127,834 |
2,838,789 |
3,773,333 |
4 |
Jun 06, 07:30 PM |
| QVT Associates GP LLC |
10% Owner |
Jun 03 |
Sale |
$22.68 |
90,169 |
2,045,355 |
3,838,288 |
4 |
Jun 06, 07:30 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
Jun 01 |
Sale |
$24.15 |
28,200 |
681,030 |
58,861 |
4 |
Jun 03, 06:26 PM |
| PALEKAR ROHAN |
Chief Commercial Officer |
Apr 20 |
Option Exercise |
$15.71 |
12,500 |
196,375 |
29,166 |
4 |
Apr 21, 05:17 PM |
| PALEKAR ROHAN |
Chief Commercial Officer |
Apr 20 |
Sale |
$22.63 |
12,500 |
282,825 |
16,666 |
4 |
Apr 21, 05:17 PM |
| PALEKAR ROHAN |
Chief Commercial Officer |
Mar 21 |
Sale |
$16.05 |
7,500 |
120,375 |
16,666 |
4 |
Mar 22, 04:36 PM |
| Seely Lynn |
Chief Medical Officer |
Mar 15 |
Option Exercise |
$3.60 |
50,000 |
180,000 |
66,666 |
4 |
Mar 17, 05:14 PM |
| Seely Lynn |
Chief Medical Officer |
Mar 15 |
Sale |
$16.48 |
50,000 |
823,885 |
16,666 |
4 |
Mar 17, 05:14 PM |
| Hung David |
President and CEO |
Feb 23 |
Option Exercise |
$16.96 |
50,000 |
848,150 |
1,232,974 |
4 |
Feb 24, 06:26 PM |
| Hung David |
President and CEO |
Feb 22 |
Option Exercise |
$17.20 |
100,000 |
1,719,990 |
1,282,974 |
4 |
Feb 24, 06:26 PM |
| Hung David |
President and CEO |
Feb 24 |
Option Exercise |
$16.41 |
50,000 |
820,430 |
1,182,974 |
4 |
Feb 24, 06:26 PM |
| Seely Lynn |
Chief Medical Officer |
Feb 15 |
Option Exercise |
$3.60 |
50,000 |
180,000 |
66,666 |
4 |
Feb 16, 05:37 PM |
| Seely Lynn |
Chief Medical Officer |
Feb 15 |
Sale |
$17.97 |
50,000 |
898,320 |
16,666 |
4 |
Feb 16, 05:37 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
Feb 10 |
Sale |
$17.06 |
14,000 |
238,819 |
94,061 |
4 |
Feb 11, 04:55 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
Feb 09 |
Sale |
$15.55 |
2,800 |
43,530 |
101,061 |
4 |
Feb 11, 04:55 PM |
| Machado Clarence Patrick |
Chief Business Officer and CFO |
Feb 07 |
Sale |
$15.51 |
4,200 |
65,130 |
120,527 |
4 |
Feb 08, 08:11 PM |
| Seely Lynn |
Chief Medical Officer |
Jan 19 |
Option Exercise |
$3.60 |
25,000 |
90,000 |
41,666 |
4 |
Jan 20, 06:12 PM |
| Seely Lynn |
Chief Medical Officer |
Jan 18 |
Option Exercise |
$3.60 |
25,000 |
90,000 |
41,666 |
4 |
Jan 20, 06:12 PM |
| Seely Lynn |
Chief Medical Officer |
Jan 18 |
Sale |
$15.59 |
25,000 |
389,740 |
16,666 |
4 |
Jan 20, 06:12 PM |
| Seely Lynn |
Chief Medical Officer |
Jan 19 |
Sale |
$14.45 |
25,000 |
361,212 |
16,666 |
4 |
Jan 20, 06:12 PM |
| QVT Associates GP LLC |
10% Owner |
Nov 29 |
Buy |
$11.00 |
200 |
2,200 |
3,968,631 |
4 |
Dec 01, 05:18 PM |
| QVT Associates GP LLC |
10% Owner |
Nov 23 |
Buy |
$10.99 |
2,100 |
23,079 |
3,968,431 |
4 |
Nov 26, 02:20 PM |
| QVT Associates GP LLC |
10% Owner |
Oct 27 |
Buy |
$11.42 |
14,901 |
170,169 |
3,965,931 |
4 |
Oct 28, 07:31 PM |
| QVT Associates GP LLC |
10% Owner |
Oct 26 |
Buy |
$11.44 |
40,914 |
468,056 |
3,951,030 |
4 |
Oct 28, 07:31 PM |
| QVT Associates GP LLC |
10% Owner |
Oct 22 |
Buy |
$11.28 |
134,470 |
1,516,796 |
3,887,390 |
4 |
Oct 26, 07:21 PM |
| QVT Associates GP LLC |
10% Owner |
Oct 25 |
Buy |
$11.28 |
22,726 |
256,349 |
3,910,116 |
4 |
Oct 26, 07:21 PM |
| QVT Associates GP LLC |
10% Owner |
Sep 17 |
Buy |
$11.49 |
8,823 |
101,376 |
3,752,920 |
4 |
Sep 20, 05:17 PM |
| QVT Associates GP LLC |
10% Owner |
Sep 16 |
Buy |
$11.49 |
20,827 |
239,242 |
3,744,097 |
4 |
Sep 20, 05:17 PM |
| QVT Associates GP LLC |
10% Owner |
Sep 14 |
Buy |
$11.47 |
31,469 |
361,081 |
3,723,270 |
4 |
Sep 16, 05:28 PM |
| QVT Associates GP LLC |
10% Owner |
Sep 13 |
Buy |
$11.50 |
3,400 |
39,100 |
3,691,801 |
4 |
Sep 14, 08:47 PM |
| QVT Associates GP LLC |
10% Owner |
Sep 10 |
Buy |
$11.44 |
178,285 |
2,040,266 |
3,688,401 |
4 |
Sep 14, 08:47 PM |
