| Owner |
Relationship |
Date |
Transaction |
Cost |
# Shares |
Value($) |
Total Shares |
Form |
Form 4 |
| Bujarski Robert Joseph |
SVP, Bus Dev & Gen Counsel |
May 17 |
Option Exercise |
$8.50 |
19,196 |
163,166 |
69,356 |
4 |
May 17, 08:07 PM |
| Bujarski Robert Joseph |
SVP, Bus Dev & Gen Counsel |
May 15 |
Option Exercise |
$8.50 |
8,283 |
70,406 |
58,443 |
4 |
May 17, 08:07 PM |
| Bujarski Robert Joseph |
SVP, Bus Dev & Gen Counsel |
May 15 |
Sale |
$23.35 |
8,283 |
193,428 |
50,160 |
4 |
May 17, 08:07 PM |
| Bujarski Robert Joseph |
SVP, Bus Dev & Gen Counsel |
May 17 |
Sale |
$23.02 |
19,196 |
441,948 |
50,160 |
4 |
May 17, 08:07 PM |
| Bujarski Robert Joseph |
SVP, Bus Dev & Gen Counsel |
Apr 10 |
Option Exercise |
$22.60 |
3,181 |
71,891 |
50,160 |
4 |
Apr 11, 07:35 PM |
| TAMERIUS JOHN |
SVP - Clinical/Reg Affairs |
Feb 28 |
Option Exercise |
$8.09 |
28,852 |
233,523 |
57,426 |
4 |
Mar 01, 08:25 PM |
| TAMERIUS JOHN |
SVP - Clinical/Reg Affairs |
Feb 22 |
Sale |
$22.40 |
24,700 |
553,364 |
28,574 |
4 |
Feb 22, 09:22 PM |
| TAMERIUS JOHN |
SVP - Clinical/Reg Affairs |
Feb 21 |
Sale |
$22.33 |
1,300 |
29,032 |
53,474 |
4 |
Feb 22, 09:22 PM |
| BRYANT DOUGLAS C |
President & CEO |
Jan 18 |
Option Exercise |
$21.36 |
3,681 |
78,626 |
200,417 |
4/A |
Jan 24, 05:00 PM |
| TAMERIUS JOHN |
SVP - Clinical/Reg Affairs |
Jan 18 |
Option Exercise |
$21.36 |
943 |
20,142 |
54,574 |
4/A |
Jan 23, 08:20 PM |
| Stenzel Timothy Todd |
Chief Science Officer |
Jan 18 |
Option Exercise |
$21.36 |
1,022 |
21,830 |
16,670 |
4/A |
Jan 23, 08:18 PM |
| McLeod Scot M |
SVP - Operations |
Jan 18 |
Option Exercise |
$21.36 |
927 |
19,801 |
34,486 |
4/A |
Jan 23, 08:16 PM |
| Bujarski Robert Joseph |
SVP, General Counsel & Secy |
Jan 18 |
Option Exercise |
$21.36 |
1,151 |
24,585 |
53,341 |
4/A |
Jan 23, 08:15 PM |
| TAMERIUS JOHN |
SVP - Clinical/Reg Affairs |
Jan 18 |
Option Exercise |
$21.36 |
2,151 |
45,945 |
54,574 |
4 |
Jan 22, 09:57 PM |
| McLeod Scot M |
SVP - Operations |
Jan 18 |
Option Exercise |
$21.36 |
2,114 |
45,155 |
34,486 |
4 |
Jan 22, 09:50 PM |
| Bujarski Robert Joseph |
SVP, General Counsel & Secy |
Jan 18 |
Option Exercise |
$21.36 |
2,356 |
50,324 |
53,341 |
4 |
Jan 22, 09:40 PM |
| Stenzel Timothy Todd |
Chief Science Officer |
Jan 18 |
Option Exercise |
$21.36 |
2,331 |
49,790 |
16,670 |
4 |
Jan 22, 09:32 PM |
| BRYANT DOUGLAS C |
President & CEO |
Jan 18 |
Option Exercise |
$21.36 |
6,442 |
137,601 |
197,656 |
4 |
Jan 22, 09:29 PM |
| TAMERIUS JOHN |
SVP - Clinical/Reg Affairs |
Dec 07 |
Option Exercise |
$3.19 |
9,000 |
28,710 |
51,214 |
4 |
Dec 11, 08:33 PM |
| POLAN MARY LAKE PH D |
Director |
Dec 06 |
Option Exercise |
$7.34 |
22,081 |
162,017 |
39,611 |
4 |
Dec 10, 06:40 PM |
| TAMERIUS JOHN |
SVP - Clinical/Reg Affairs |
Dec 04 |
Sale |
$18.23 |
4,000 |
72,924 |
42,214 |
4 |
Dec 06, 05:34 PM |
| Brown Thomas D |
Director |
Nov 29 |
Option Exercise |
$9.93 |
5,331 |
52,937 |
24,228 |
4 |
Nov 29, 07:56 PM |
| Brown Thomas D |
Director |
Nov 27 |
Option Exercise |
$9.93 |
4,000 |
39,720 |
22,897 |
4 |
Nov 29, 07:56 PM |
| Brown Thomas D |
Director |
Nov 29 |
Sale |
$17.31 |
5,331 |
92,283 |
18,897 |
4 |
Nov 29, 07:56 PM |
| Brown Thomas D |
Director |
Nov 27 |
Sale |
$17.31 |
4,000 |
69,242 |
18,897 |
4 |
Nov 29, 07:56 PM |
| BRYANT DOUGLAS C |
President & CEO |
May 03 |
Buy |
$15.78 |
10,000 |
157,757 |
204,098 |
4 |
May 03, 06:42 PM |
| BRYANT DOUGLAS C |
President & CEO |
Feb 02 |
Option Exercise |
$14.51 |
9,163 |
132,955 |
184,098 |
4 |
Mar 21, 09:10 PM |
| BRYANT DOUGLAS C |
President & CEO |
Jan 18 |
Option Exercise |
$15.14 |
5,028 |
76,124 |
193,261 |
4 |
Mar 21, 09:10 PM |
| BRYANT DOUGLAS C |
President & CEO |
Mar 19 |
Buy |
$16.55 |
10,000 |
165,462 |
194,098 |
4 |
Mar 21, 09:10 PM |
| SCHULER JACK W |
Director |
Mar 21 |
Buy |
$16.65 |
40,000 |
665,928 |
3,311,465 |
4 |
Mar 21, 07:02 PM |
| SCHULER JACK W |
Director |
Mar 20 |
Buy |
$16.48 |
15,815 |
260,577 |
3,271,465 |
4 |
Mar 21, 07:02 PM |
| SCHULER JACK W |
Director |
Mar 19 |
Buy |
$16.60 |
10,000 |
165,954 |
3,255,650 |
4 |
Mar 21, 07:02 PM |
| TAMERIUS JOHN |
SVP - Clinical/Reg Affairs |
Mar 15 |
Sale |
$16.16 |
3,500 |
56,549 |
48,914 |
4 |
Mar 16, 06:25 PM |
| Brown Thomas D |
Director |
Mar 09 |
Option Exercise |
$5.59 |
5,482 |
30,644 |
19,310 |
4 |
Mar 13, 06:36 PM |
| Brown Thomas D |
Director |
Mar 09 |
Sale |
$16.13 |
5,482 |
88,425 |
13,828 |
4 |
Mar 13, 06:36 PM |
| TAMERIUS JOHN |
SVP - Clinical/Reg Affairs |
Feb 21 |
Option Exercise |
$5.70 |
5,625 |
32,062 |
44,408 |
4 |
Mar 06, 08:24 PM |
| TAMERIUS JOHN |
SVP - Clinical/Reg Affairs |
Feb 21 |
Option Exercise |
$5.70 |
5,625 |
32,062 |
44,408 |
4 |
Mar 06, 08:18 PM |
| POLAN MARY LAKE PH D |
Director |
Mar 05 |
Buy |
$15.12 |
2,000 |
30,241 |
16,930 |
4 |
Mar 06, 08:09 PM |
| PULIDO MARK |
Director |
Oct 26 |
Option Exercise |
$5.35 |
13,730 |
73,448 |
28,660 |
4 |
Oct 26, 06:31 PM |
| PULIDO MARK |
Director |
Oct 26 |
Sale |
$17.09 |
13,730 |
234,615 |
14,930 |
4 |
Oct 26, 06:31 PM |
| PULIDO MARK |
Director |
Oct 05 |
Option Exercise |
$5.08 |
8,600 |
43,688 |
23,530 |
4 |
Oct 07, 06:25 PM |
| PULIDO MARK |
Director |
Oct 07 |
Option Exercise |
$5.08 |
10,670 |
54,204 |
25,600 |
4 |
Oct 07, 06:25 PM |
| PULIDO MARK |
Director |
Oct 06 |
Option Exercise |
$5.08 |
17,000 |
86,360 |
31,930 |
4 |
Oct 07, 06:25 PM |
| PULIDO MARK |
Director |
Oct 06 |
Sale |
$17.03 |
17,000 |
289,452 |
14,930 |
4 |
Oct 07, 06:25 PM |
| PULIDO MARK |
Director |
Oct 05 |
Sale |
$17.02 |
8,600 |
146,351 |
14,930 |
4 |
Oct 07, 06:25 PM |
| PULIDO MARK |
Director |
Oct 07 |
Sale |
$17.04 |
10,670 |
181,824 |
14,930 |
4 |
Oct 07, 06:25 PM |
| TAMERIUS JOHN |
SVP - Clinical/Reg Affairs |
Aug 09 |
Buy |
$13.25 |
750 |
9,936 |
38,783 |
4 |
Aug 10, 06:04 PM |
| SCHULER JACK W |
Director |
Aug 05 |
Buy |
$14.07 |
20,865 |
293,639 |
3,168,153 |
4 |
Aug 09, 07:47 PM |
| SCHULER JACK W |
Director |
Aug 08 |
Buy |
$13.99 |
79,135 |
1,107,494 |
3,247,288 |
4 |
Aug 09, 07:47 PM |
| BRYANT DOUGLAS C |
President & CEO |
Aug 05 |
Buy |
$13.89 |
20,000 |
277,808 |
194,396 |
4 |
Aug 09, 07:45 PM |
| Bujarski Robert Joseph |
SVP, General Counsel & Secy |
Jun 09 |
Option Exercise |
$15.45 |
20,992 |
324,326 |
56,464 |
4 |
Jun 13, 02:39 PM |
| BRYANT DOUGLAS C |
President & CEO |
Jun 08 |
Buy |
$15.18 |
5,000 |
75,885 |
174,396 |
4 |
Jun 09, 07:09 PM |
| BRYANT DOUGLAS C |
President & CEO |
Jun 07 |
Buy |
$14.96 |
5,000 |
74,820 |
169,396 |
4 |
Jun 09, 07:09 PM |
| SMITS MARK W |
SVP-Commercial Operations |
Jun 01 |
Option Exercise |
$0.01 |
9,136 |
91 |
9,136 |
4 |
Jun 03, 05:37 PM |
| SCHULER JACK W |
Director |
May 05 |
Buy |
$13.66 |
409 |
5,585 |
3,147,288 |
4 |
May 06, 06:20 PM |
| SCHULER JACK W |
Director |
May 03 |
Buy |
$13.01 |
4,591 |
59,746 |
3,146,879 |
4 |
May 05, 06:05 PM |
| BRYANT DOUGLAS C |
President & CEO |
May 03 |
Buy |
$13.07 |
2,500 |
32,670 |
163,496 |
4 |
May 05, 06:02 PM |
| BRYANT DOUGLAS C |
President & CEO |
May 05 |
Buy |
$13.49 |
900 |
12,141 |
164,396 |
4 |
May 05, 06:02 PM |
| BRYANT DOUGLAS C |
President & CEO |
Feb 02 |
Option Exercise |
$13.90 |
10,212 |
141,947 |
160,996 |
4 |
Mar 14, 01:23 PM |
| SCHULER JACK W |
Director |
Jan 11 |
Option Exercise |
$13.15 |
475,000 |
6,246,250 |
3,142,288 |
4 |
Jan 21, 06:43 PM |
| RADAK JOHN MATTHEW |
Chief Financial Officer |
Jan 03 |
Option Exercise |
$14.74 |
62 |
914 |
20,927 |
4 |
Jan 05, 09:55 PM |
| McLeod Scot M |
SVP - Operations |
Jan 03 |
Option Exercise |
$14.74 |
1,674 |
24,675 |
37,182 |
4 |
Jan 05, 09:51 PM |
| Bujarski Robert Joseph |
SVP, General Counsel & Secy |
Jan 03 |
Option Exercise |
$14.74 |
588 |
8,667 |
77,456 |
4 |
Jan 05, 09:50 PM |
| BRYANT DOUGLAS C |
President & CEO |
Jan 03 |
Option Exercise |
$14.74 |
2,440 |
35,966 |
171,208 |
4 |
Jan 05, 09:48 PM |
